Long‐term efficacy of thalamic deep brain stimulation for tremor: Double‐blind assessments
Identifieur interne : 004049 ( Main/Exploration ); précédent : 004048; suivant : 004050Long‐term efficacy of thalamic deep brain stimulation for tremor: Double‐blind assessments
Auteurs : Stig Rehncrona [Suède] ; Bo Johnels [Suède] ; H Kan Widner [Suède] ; Anna-Lena Törnqvist [Suède] ; Marwan Hariz [Suède] ; Olof Sydow [Suède]Source :
- Movement Disorders [ 0885-3185 ] ; 2003-02.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Homme.
English descriptors
- KwdEn :
- Aged, Chronic, Disease Progression, Double-Blind Method, Electric Stimulation Therapy (methods), Essential Tremor (epidemiology), Essential Tremor (etiology), Essential Tremor (therapy), Female, Follow-Up Studies, Human, Humans, Instrumental stimulation, Long term, Male, Observer Variation, Parkinson Disease (complications), Parkinson's disease, Thalamus, Thalamus (physiology), Time, Treatment efficiency, Tremor, Ventromedial nucleus, deep brain stimulation, double‐blind assessments, essential tremor, long‐term results, thalamus Vim.
- MESH :
- complications : Parkinson Disease.
- epidemiology : Essential Tremor.
- etiology : Essential Tremor.
- methods : Electric Stimulation Therapy.
- physiology : Thalamus.
- therapy : Essential Tremor.
- Aged, Disease Progression, Double-Blind Method, Female, Follow-Up Studies, Humans, Male, Observer Variation, Time.
Abstract
Thalamic deep brain stimulation (DBS) is proven to suppress tremor in Parkinson's disease (PD) and essential tremor (ET). However, there are few reports on its long‐term efficacy. We studied the efficacy of DBS at 2 years and 6–7 years after electrode implantations in the ventrointermediate nucleus of the thalamus in 39 patients (20 PD, 19 ET) with severe tremor. Twenty‐five of the patients completed the study. Evaluations were done in a double‐blind manner with the Unified Parkinson's Disease Rating Scale (UPDRS) and Essential Tremor Rating Scale (ETRS). DBS decreased tremor sum scores in PD (P < 0.025) compared to the preoperative baseline (median, 7; Q25–75, 6–9) both at 2 years (median, 2; Q25–75, 2–3.5; n = 16) and at 6 to 7 years (median, 2.5; Q25–75, 0.5–3; n = 12). Stimulation on improved tremor sum as well as sub scores (P < 0.025) compared to stimulation off conditions. In ET, thalamic stimulation improved (P < 0.025) kinetic and positional tremor at both follow‐up periods (n = 18 and n = 13, respectively) with significant improvements (P < 0.025) in hand‐function tests. PD but not ET patients showed a general disease progression. Stimulation parameters were remarkably stable over time. We conclude that high‐frequency electric thalamic stimulation can efficiently suppress severe tremor in PD and ET more than 6 years after permanent implantation of brain electrodes. © 2002 Movement Disorder Society
Url:
DOI: 10.1002/mds.10309
Affiliations:
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Le document en format XML
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Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>New York</pubPlace><date type="published" when="2003-02">2003-02</date><biblScope unit="vol">18</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="163">163</biblScope><biblScope unit="page" to="170">170</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">247D16C980151DE317664B109F33A423ADC38546</idno><idno type="DOI">10.1002/mds.10309</idno><idno type="ArticleID">MDS10309</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Chronic</term><term>Disease Progression</term><term>Double-Blind Method</term><term>Electric Stimulation Therapy (methods)</term><term>Essential Tremor (epidemiology)</term><term>Essential Tremor (etiology)</term><term>Essential Tremor (therapy)</term><term>Female</term><term>Follow-Up Studies</term><term>Human</term><term>Humans</term><term>Instrumental stimulation</term><term>Long term</term><term>Male</term><term>Observer Variation</term><term>Parkinson Disease (complications)</term><term>Parkinson's disease</term><term>Thalamus</term><term>Thalamus (physiology)</term><term>Time</term><term>Treatment efficiency</term><term>Tremor</term><term>Ventromedial nucleus</term><term>deep brain stimulation</term><term>double‐blind assessments</term><term>essential tremor</term><term>long‐term results</term><term>thalamus Vim</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Essential Tremor</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Essential Tremor</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Electric Stimulation Therapy</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Thalamus</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Essential Tremor</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Disease Progression</term><term>Double-Blind Method</term><term>Female</term><term>Follow-Up Studies</term><term>Humans</term><term>Male</term><term>Observer Variation</term><term>Time</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Chronique</term><term>Efficacité traitement</term><term>Homme</term><term>Long terme</term><term>Noyau ventromédial</term><term>Stimulation instrumentale</term><term>Thalamus</term><term>Tremblement</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="fr">Thalamic deep brain stimulation (DBS) is proven to suppress tremor in Parkinson's disease (PD) and essential tremor (ET). However, there are few reports on its long‐term efficacy. We studied the efficacy of DBS at 2 years and 6–7 years after electrode implantations in the ventrointermediate nucleus of the thalamus in 39 patients (20 PD, 19 ET) with severe tremor. Twenty‐five of the patients completed the study. Evaluations were done in a double‐blind manner with the Unified Parkinson's Disease Rating Scale (UPDRS) and Essential Tremor Rating Scale (ETRS). DBS decreased tremor sum scores in PD (P < 0.025) compared to the preoperative baseline (median, 7; Q25–75, 6–9) both at 2 years (median, 2; Q25–75, 2–3.5; n = 16) and at 6 to 7 years (median, 2.5; Q25–75, 0.5–3; n = 12). Stimulation on improved tremor sum as well as sub scores (P < 0.025) compared to stimulation off conditions. In ET, thalamic stimulation improved (P < 0.025) kinetic and positional tremor at both follow‐up periods (n = 18 and n = 13, respectively) with significant improvements (P < 0.025) in hand‐function tests. PD but not ET patients showed a general disease progression. Stimulation parameters were remarkably stable over time. We conclude that high‐frequency electric thalamic stimulation can efficiently suppress severe tremor in PD and ET more than 6 years after permanent implantation of brain electrodes. © 2002 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>Suède</li></country><region><li>Götaland</li><li>Suède occidentale</li><li>Svealand</li></region><settlement><li>Göteborg</li><li>Stockholm</li></settlement><orgName><li>Université de Göteborg</li></orgName></list><tree><country name="Suède"><noRegion><name sortKey="Rehncrona, Stig" sort="Rehncrona, Stig" uniqKey="Rehncrona S" first="Stig" last="Rehncrona">Stig Rehncrona</name></noRegion><name sortKey="Hariz, Marwan" sort="Hariz, Marwan" uniqKey="Hariz M" first="Marwan" last="Hariz">Marwan Hariz</name><name sortKey="Johnels, Bo" sort="Johnels, Bo" uniqKey="Johnels B" first="Bo" last="Johnels">Bo Johnels</name><name sortKey="Sydow, Olof" sort="Sydow, Olof" uniqKey="Sydow O" first="Olof" last="Sydow">Olof Sydow</name><name sortKey="Tornqvist, Anna Ena" sort="Tornqvist, Anna Ena" uniqKey="Tornqvist A" first="Anna-Lena" last="Törnqvist">Anna-Lena Törnqvist</name><name sortKey="Widner, H Kan" sort="Widner, H Kan" uniqKey="Widner H" first="H Kan" last="Widner">H Kan Widner</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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